Antidromic tachycardia due to an accessory pathway

Tracing
N° 72
Patient
63-year-old man with multiple risk factors hospitalized for palpitations; ECG recorded during a well-hemodynamically supported tachycardia episode;
Antidromic tachycardia due to an accessory pathway
Antidromic tachycardia due to an accessory pathway
Antidromic tachycardia due to an accessory pathway
Antidromic tachycardia due to an accessory pathway
Comments

This patient presented a masked left lateral accessory pathway (anterograde conduction only visible after Adenosine injection) and episodes of orthodromic (narrow QRS) and antidromic (broad QRS, major pre-excitation pattern) tachycardia. This clinical case illustrates the difficulty of diagnosing an antidromic tachycardia mistaken for a ventricular tachycardia.

Orthodromic tachycardias are the most common arrhythmias encountered clinically in patients with Wolff-Parkinson-White syndrome. Antidromic tachycardias, in which the circuit is reversed, are much rarer since only documented in approximately 5% of patients with accessory pathway or in less than 10% of patients with inducible tachycardias in the electrophysiology laboratory. The impulse descends from the atrium to the ventricles through an accessory bundle (anterograde conduction) and ascends toward the atrium in a retrograde manner through the nodo-Hisian pathway before once again descending through the accessory pathway. In rare cases, the impulse may ascend back to the atria through a second accessory pathway. The onset of this type of tachycardia requires a unidirectional block in one of the two atrioventricular conduction pathways. Unlike orthodromic tachycardias, an atrial extrasystole is conducted in anterograde manner through the bundle of Kent but is blocked by the normal pathways, or a ventricular extrasystole ascends through normal conduction pathways but is blocked in the bundle of Kent. Various studies suggest that antidromic tachycardias are preferentially observed in patients with multiple accessory pathways or with a lateral accessory pathway located remotely from the atrioventricular node. It appears that in order to induce this arrhythmia, a minimum critical distance is necessary, the impulse needing to be blocked in the node, conducted through the accessory pathway, reach the ventricular apex and then return back up to the node to allow retrograde conduction to the atria without encountering the conduction pathways in refractory period.

The management of antidromic tachycardias is sometimes difficult given their rarity and their electrocardiographic pattern of wide QRS tachycardia (ventricular activation is exclusively through the accessory pathway), which can lead to suspecting the diagnosis of ventricular tachycardia.

An antidromic tachycardia presents a poorly-specific electrocardiographic pattern that must be differentiated from a 1:1 supraventricular arrhythmia with conduction aberration and a ventricular tachycardia with retrograde conduction. The diagnosis is sometimes difficult, as in this patient, when the presence of the accessory pathway is unknown and that the pre-excitation is not visible on the sinus complexes (masked left lateral pathway).

The electrocardiogram shows:

- A rapid, regular, wide QRS tachycardia
- A preexcited atrial fibrillation pattern (substantial and maximum pre-excitation) since the entire ventricular activation originates from the accessory pathway
- The absence of capture or fusion complexes (differential diagnosis with a ventricular tachycardia
- 1:1 relationship between atria and ventricles
- The RP' interval is longer than for an intranodal reentry
- The retrograde P' wave pattern is the same as for an intranodal reentry since dependent on the atrioventricular node (negative in the inferior leads); the atrial activity is often difficult to analyze since occurring in the T wave of the preceding QRS

The highlighting of antidromic tachycardia may constitute a factor of poor prognosis since it is associated with an increased risk of malignant forms. Indeed, this type of tachycardia is more frequently observed in patients with multiple accessory pathways. In addition, it appears that the occurrence of antidromic tachycardia is a marker of good conductivity throughout the pathway.

Epigraph
Antidromic tachycardias are less frequent than orthodromic tachycardia; the impulse descends from the atrium to the ventricles through the accessory bundle and ascends in retrograde manner toward the atrium through the nodo-Hisian pathway; this is a regular wide QRS tachycardia (maximum pre-excitation pattern) with a 1:1 AV ratio;
Antidromic tachycardia due to an accessory pathway
Antidromic tachycardia due to an accessory pathway